Clinician-Endorsed Products

Products Dr. Paul actually uses.

Every product on this page has been evaluated and used in Dr. Petrungaro's own surgical practice. Nothing appears here because a company asked — it appears because it earned a place in real cases, on real patients, with results worth passing on to you.

Product 01EVOBIO

Exo Perio

Growth factors in surgical dentistry

Exo Perio™ delivers exosomes — extracellular vesicles secreted from the membranes of mesenchymal stem cells, roughly 30–150 nm in diameter. They are the messenger particles of cell-to-cell communication, carrying growth factors, cytokines and proteins to the tissue that needs them. Acellular by design: the signaling machinery of stem cells, without the cells.

Ø ~30–150 nm · Wharton's Jelly (age-0 tissue) · Allogeneic · Acellular · Single-use sterile vial

Indications

Where it's used

Bone grafts
Periodontal surgeries
Root coverage
Implant sites
Extraction sockets
Furcation defects
Intrabody defects
Sinus lifts
Advanced cases requiring stem-cell-based regeneration

Source & regenerative capacity

Why Wharton's Jelly matters

Exo Perio™ is a minimally manipulated allograft derived from Wharton's Jelly — the gelatinous tissue that cushions the umbilical cord. It is an immuno-privileged site, and it carries the highest concentration of mesenchymal stem cells and exosomes available. Because of its source, it bears no antigens, so patient rejection is extremely rare.

Age-0 tissue

Highest regenerative capacity

Unlike autologous options, potency isn't limited by the age or health of your patient. Wharton's Jelly is age-0 tissue, carrying the highest concentration of growth factors and proteins that stimulate periodontal tissue regeneration and bone density, and accelerate healing.

Sourcing & safety

Lab-controlled, tested, retested

Procured from an FDA-registered lab and a tissue bank compliant with FDA regulations, with extensive donor serology panels and testing to ensure the product is free of bacterial and fungal contaminants. ISO 5 compliant. Every vial is tested and retested.

What they consist of

Composition

LipidsProteinsNucleic AcidsCytokinesAcellular

Where they help

Beneficial effects

  • Inflammation
  • Autoimmunity
  • Regeneration
300+

Growth factors responsible for wound repair and tissue regeneration, carried within these extracellular vesicles.

Advantages

Why clinicians choose Exo Perio™

Long-term release of growth factors

Sustained delivery rather than a single burst.

Long-term effects from stem cell activity

Ongoing regenerative signaling over time.

Anti-inflammatory, antimicrobial & antiviral

Also angiogenic and antifibrotic.

Immuno-privileged & allogeneic

Bears no antigens; patient rejection is extremely rare.

Acellular — no graft-versus-host risk

Containing no cells, there is no risk of graft-versus-host disease.

Off-the-shelf use

No preparation workflow, no centrifuge, no chair-time cost.

No blood draw

Nothing collected from the patient.

Cost-effective, single-use sterile vials

Predictable per-case economics.

Periodontal regeneration supported by clinical studies

See Limitations below for an honest read on the current depth of the evidence base.

Comparison

Exo Perio™ against the alternatives

How exosome therapy compares with the regenerative options most practices already run.

PRP PRF Emdogain Exo Perio™
Source Autologous (centrifugation to isolate plasma) Autologous (centrifugation without anticoagulants) Porcine enamel matrix proteins Wharton's Jelly (age-0) MSC exosomes and growth factors
Main components Platelets, growth factors (PDGF, TGF-β, VEGF) Platelets, growth factors (PDGF, TGF-β, VEGF) Amelogenins and other matrix proteins Growth factors, cytokines, exosomes, extracellular matrix
Blood draw Yes Yes No No
Cost Moderate Low Low Moderate
Sterility Sterility preparation process Non-sterile preparation process Sterile Sterile
Efficacy Only as efficacious as the youth of the patient Only as efficacious as the youth of the patient Low efficacy Very efficacious

→ Scroll the table horizontally on smaller screens

Cost

What it costs, and what it returns

Price PRP PRF Emdogain Exo Perio™
Upfront cost $2,000 – $5,000
(PRP kit $149–$499)
$1,500 – $2,500
(PRF kit $59–$199)
$250 – $500 per patient $250 or less per 2cc vial
$500 or less per 5cc vial
Insurance coverage Yes (some cases) Yes (some cases) Yes No — cash-flow business model
Customary charge per patient $500 – $1,000 $250 – $500 $250 – $500 $500 – $2,500

Full picture

Limitations worth knowing

No material is right for every case. These are the trade-offs to plan around.

  • Rapid resorption if not stored properly.
  • Less scaffolding support — though greater regenerative potential.
  • Limited shelf life once thawed.
  • Clinical studies and adoption are still limited compared with established options.

5 Top Points

01

Anti-inflammatory, antiviral & antimicrobial

02

Long-term release of growth factors

03

Over 300 growth factors for wound repair & tissue regeneration

04

Cost-effective

05

No blood draw

Bring Exo Perio™ into your practice.

Purchase Exosomes

Ordering through this link ensures your practice receives full credit and commission on every order.

A note on these endorsements

Implant Mentor Line earns a commission on products purchased through the links on this page. That relationship never determines what gets listed. Products are selected on clinical merit first, and Dr. Petrungaro uses each of them in his own practice.

Evolutionary Biologics does not offer Mesenchymal Stem Cell Exosomes or Wharton's Jelly as a cure for any condition, disease, or injury. No statements or implied treatments on this page have been evaluated or approved by the FDA. Product information is provided by the manufacturer.

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